Subprojects


Subproject No.

Partner

Short
Title of Subproject

Function
within the Consortium

Contribution

A1

Christoph Klein

Ludwig-Maximilians University Munich

Coordination unit of the consortium for primary immunodeficiency diseases

Coordination unit

Coordination, processing of results, facilitating exchanges between network partners, contact to lay-organisations and society

A2

Klaus Schwarz
Manfred Hönig

University Ulm

Genetics of human(severe) combined immunodeficiencies (SCID)

Subproject partner

Pathophysiology and
genetics of SCID, reference laboratory for genetic diagnosis

A3

Stephan Ehl
Carsten Speckmann
Anne Rensing-Ehl

University Freiburg

Genetic and immunological variability in patients with lymphoproliferation and autoimmunity

Subproject partner

Pathophysiology and
genetics of ALPS,
immunologic analysis of lymphoid
immunodeficiencies

A4

Angela Rösen-Wolff
Joachim Roesler
Manfred Gahr

University Dresden

Characterization of the molecular basis of autoinflammatory diseases

Subproject partner

Genetics and pathophysiology of
autoinflammatory disorders, platform for cellular screening assays

A5

Horst von Bernuth

Charité Berlin

New primary immunodeficiencies in innate immunity predispose to invasive pneumococcal and staphylococcal disease

Subproject partner

Pathophysiology and genetics of innate immunity, platform for TLR-signaling defects

A6

Christopher Baum
Axel Schambach

Hannover Medical
School

Cellular reprogramming platform for inherited immunodeficiencies

Subproject partner

Platform for preclinical assessment of gene transfer vectors and generation of induced pluripotent stem cells

A7

Christoph Klein

Ludwig-Maximilians University Munich

Development of stem cell gene therapies for patients with PID and colitis

Subproject partner

Development of stem cell gene therapies for patients with PID and colitis

B1

Bodo Grimbacher
Gerhard Kindle

University Freiburg

German National Registry for primary immunodeficiencies

Subproject partner

Logistics and maintenance
of national registry for patients with PID